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criptId":"ENST00000497784","entrezGeneId":"673","consequenceTerms":"3_prime_UTR_variant,NMD_transcript_variant","hugoGeneSymbol":"BRAF","hgvsc":"ENST00000497784.1:c.*1249T>A","variantClassification":"3'UTR","exon":"16/19"}],"transcriptConsequenceSummary":{"transcriptId":"ENST00000288602","codonChange":"gTg/gAg","aminoAcids":"V/E","aminoAcidRef":"V","aminoAcidAlt":"E","entrezGeneId":"673","consequenceTerms":"missense_variant","hugoGeneSymbol":"BRAF","hgvspShort":"p.V600E","hgvsp":"p.Val600Glu","hgvsc":"ENST00000288602.6:c.1799T>A","proteinPosition":{"start":600,"end":600},"refSeq":"NM_004333.4","variantClassification":"Missense_Mutation","exon":"15/18","polyphenScore":0.963,"polyphenPrediction":"probably_damaging","siftScore":0.0,"siftPrediction":"deleterious","uniprotId":"P15056","alphaMissense":{"score":0.9927,"pathogenicity":"pathogenic"}}}}